As KromoGEN Biotechnology, we offer solutions suitable for your needs with our clinical genetics product portfolio spread over a wide range of application areas from molecular genetic diagnosis to pharmacogenomics, cancer genetics to prenatal diagnosis.

Molecular genetic methods are frequently used in the diagnosis and treatment monitoring of genetically based diseases. We have two solution partners in the field of molecular genetic diagnosis. These are Nanodigmbio and Helix DNA Technologies.

NadAuto-16R Fully-automated NGS Workstation

NadAuto-16R consists of a host computer, integrated terminal and control software. The host includes a 3D robotic arm, a liquid handling module, 2 temperature control modules, a thermal cycler, a heating and oscillation module and a host frame. The host has 12 standard SBS built-in plate positions, allowing flexible combination of functional modules, carrier and consumables to meet the needs of various scenarios and sample quantities. Meanwhile, it is accompanied by a liquid handling module with a plate holder that supports the loading of 8-channel pipetting tips and 1/8 pipette tips, enabling flexible configuration according to sample quantities, thus improving efficiency and effortlessly facilitating plate transfer.
NadAuto-16R is not only applicable for automated sample processing and loading, including sample dispensing, nucleic acid extraction, enzyme reaction system preparation, nucleic acid purification, quantitative loading and sample mixing, but also for automated preparation of gene sequencing libraries and hybridization capture in clinical diagnostics, which can comprehensively improve laboratory efficiency.
For more details: Product webpage

Heliks DNA Technologies, founded in Istanbul, Turkey, offers a wide product portfolio for the detection of many genetic-based diseases, from beta thalassemia to thrombophilia, from cystic fibrosis to familial mediterranean fever, with its minidarray-based products designed, developed and validated for the diagnosis of hereditary diseases.

Already in use in universities, hospitals and private genetic diagnostic laboratories across Turkey, these products are designed to be used with AppliedBiosystems genetic analyzers. You can find our full product portfolio here.

Heliks also offers validated sequencing kits for many diseases. Please contact us for more information.

The use of molecular biology methods in the detection and characterization of microorganisms has revolutionized the field of diagnostic microbiology. The rapid and accurate detection of pathogenic microorganisms by PCR-based methods has eliminated the need for cell culture and enabled results to be obtained in a shorter time. Our solution partner in pathogen detection HEALTH Gene Technologies, has a wide range of products in this field.

SureX® HCV & IL28B Genotyping Multiplex Kit

Hepatitis C virus (HCV) is a highly heterogeneous RNA virus consisting of 6 genotypes and many subtypes. HCV causes chronic hepatitis, which can later develop into liver cirrhosis and even liver cancer. SureX® HCV& IL28B Genotyping Multiplex Kit screens for the 6 most common HCV subtypes and 2 single nucleotide polymorphisms in the gene regulatory region of IL28B that modify drug efficacy. The targets that can be detected with this kit are shown in the table below.

HGT Surex HCV Table

For detailed information about the product, see our current product brochure from here you can download it.

SureX® HPV 25X Genotyping Kit

The human papilloma virus (HPV) consists of low-risk and high-risk HPV types. The low-risk types often do not cause significant disease, while the high-risk types are often associated with cervical cancer. The SureX® HPV 25X Genotyping Kit is intended to detect 25 HPV types with a single test.

For detailed information about the product, see our current product brochure from here you can download it.

SureX® Diarrhea Virus Multiplex Kit

Diarrhea is an intestinal infectious disease that can be caused by many different microorganisms. SureX® Diarrhea Virus Multiplex Kit detects 11 most common diarrhea-causing viruses in a single tube. The target microorganisms that can be detected with this kit are shown in the table below.

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For detailed information about the product, see our current product brochure from here you can download it.

SureX® Rash & Fever Virus Multiplex Kit

SureX® Rash & Fever Virus Multiplex Kit contains 11 different viruses that can cause fever and rash in one go Streptococcus pyogenes and Mycoplasma pneumonia organisms can also be detected. The target microorganisms that can be detected with this kit are shown in the table below.

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For detailed information about the product, see our current product brochure from here you can download it.

SureX® Encephalitis Virus Multiplex Kit

Meningitis can be caused by many different viruses. The main symptoms are fever, headache and meningitis irritation. Approximately % 85~95% of viral meningitis is caused by enterovirus. This is followed by mumps, herpes and adenoviruses. SureX® Encephalitis Virus Multiplex Kit simultaneously examines 20 encephalitis viruses in a single tube. The target viruses that can be detected with this kit are shown in the table below.

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For detailed information about the product, see our current product brochure from here you can download it.

SureX® Respiratory Infections Multiplex Kit

Akut solunum yolu enfeksiyonlarının neredeyse %95’i ve aşağı solunum yolları hastalıklarının çoğu virüsler nedeniyle meydana gelir. Var olan virüslerin salgınları yeni virüslerin ortaya çıkmasıyla baş edebilmek için hastaların hızlı, hassas ve çok parametreli bir yöntemle test edilmeleri gerekir. Bu sayede uygun tanı konup buna uygun tedaviler gerçekleştirilebilir. SureX® Respiratory Infections Multiplex Kit allows testing of 14 target genes of 13 common respiratory infection viruses in a single tube. The target viruses that can be detected with this kit are shown in the table below.

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A relatively new field, pharmacogenomics is concerned with how a person's genetic makeup influences their response to medicines. It is a combination of pharmacology, the science of drugs, and genomics, the study of genes and their functions. Its aim is to identify effective and safe medicines and appropriate doses in accordance with a person's genetic makeup. Today, medicines are often prescribed on the assumption that they will be effective, but it is not possible to predict who will benefit from a medicine, who will not respond to treatment at all, or who may show some side effects. With the studies conducted in the light of the information obtained from the Human Genome Project, many data are obtained on how the genetic structure of a person will affect the response of that person's body to the drug. The practical effectiveness of these data is being proven more and more every day.

As Kromogen Biotechnology, we have a wide range of products in the field of pharmacogenomics HEALTH Gene Technologies with SureX® pharmacogenomics. For more information on SureX® pharmacogenomics products, see the detailed product brochure. from here you can reach.

SureX® Multiplex Gene Expression Kit for Cancer Drugs

Recent studies have shown that the expression levels of some genes alter the efficacy of related cancer drugs. Determining the expression levels of these genes can be a guide in determining personalized methods in cancer treatment. With the SureX® Multiplex Gene Expression Kit for Cancer Drugs, the expression levels of 14 genes can be determined simultaneously to gain therapeutic insight for more than 20 cancer drugs.

The table below shows the genes and related cancer drugs whose expression levels can be detected with this kit.

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SureX® Platinum-Based Chemotherapy SNP Multiplex Kit

Platinum-based chemotherapy drugs such as carboplatin and oxaliplatin are the most commonly used anti-tumor drugs. Platinum-based drugs can have toxic effects such as hearing loss. The risks of these side effects have been associated with certain genotypes. With SureX® Platinum-Based Chemotherapy SNP Multiplex Kit, a total of 8 single nucleotide polymorphisms (SNPs) can be analyzed in TPMT, ERCC1, XRCC1 and 4 other genes.

The table below shows the single nucleotide polymorphisms that can be screened with this kit.

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SureX® CYP2C19 Genotyping Kit

CYP2C19 is one of the most important Cytochrome P450 enzymes involved in drug metabolism. SureX® CYP2C19 Genotyping Kit examines three CYP2C19 SNP loci (*2, *3 and *17) in the human genome. Studies have shown that different CYP2C19 genotypes affect enzyme activities, leading to increased or decreased metabolic rate of drugs. Therefore, CYP2C19 genotyping can help doctors predict the efficacy and side effects of certain drugs and determine appropriate medications and dosages.

The table below shows the genotypes that can be screened with this kit and their effects on drug metabolism.

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SureX® ALDH2 /ADH1B Genotyping Kit

Nitroglycerin (NTG) is a vasodilator drug and functions through the release of nitric oxide (NO). This conversion is carried out by the enzyme aldehyde dehydrogenase (encoded by the ALDH2 gene). However, the Glu504Lys mutation in the ALDH2 gene decreases NTG activity by reducing enzyme activity. In addition, alcohol dehydrogenase (encoded by the ADH1B gene) and aldehyde dehydrogenase are key enzymes in alcohol metabolism. Mutations in these two genes affect alcohol metabolism, leading to the accumulation of acetaldehyde and other harmful substances. Therefore, the ALDH2/ADH1B genetic test can also be used to test for healthy alcohol consumption.

The table below shows the genotypes that can be screened with this kit and their effects on drug metabolism.

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SureX® Warfarin SNP Multiplex Kit

Warfarin tromboembolik hastalıkların tedavisinde en sık kullanılan antikoagülandır. Warfarin’in klinik etkinliği hastadan hastaya farklılık gösterir ve doz farklılıkları 20 kata kadar çıkabilir. Tedavide dozun doğru belirlenememesi sonucu olarak kanama oldukça sık (hastaların %25’inde) görülür. Kişiler arasındaki farklılıklar ve ilaç yan etkileri CYP2C9 ve VKORC1 genlerinin metabolizmaya etkilerinden kaynaklanmaktadır. SureX® Warfarin SNP Multipleks Kiti ile warfarin metabolizmasıyla ilişkilendirilmiş tek nükleotid polimorfizmlerinin taranması tedavi için ipuçları sağlayarak hastaları yan etkilerden korur.

The table below shows the genes that can be screened with this kit and their effect on warfarin metabolism.

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SureX® 5-FU Chemo Guide SNP Multiplex Kit

Fluorouracil (5-FU) is used to treat many cancers, especially cancers of the colon and digestive system. 5-FU, an effective anti-tumor drug, can cause different side effects in different patients. These differences have been found to be caused by a mutation. Loss/reduction of the function of the DPD enzyme as a result of a DYPD mutation can lead to fatal side effects in patients receiving 5-FU treatment. With the SureX® 5-FU Chemotherapy Multiplex Kit, 8 SNPs in 7 cancer-related genes can be screened to predict side effects and adjust the drug dose. These genes are shown in the table below:

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Every individual is different, and so is their cancer. Nowadays, when personalized treatments are rapidly becoming widespread, it is no longer a dream to treat cancer by taking into account the genetic structure of the person and the type of cancer.

Personal Genome Diagnostics, founded by Johns Hopkins University researchers, of which we are the sole authorized representative, offers personalized cancer genome analysis service packages. The analyzes are aimed at detecting genomic variations that may shed light on the biological basis of cancer. The report generated as a result of the test includes a detailed analysis of the parameters examined, as well as personalized medication and treatment recommendations, including the latest developments in the world.

In addition to tumor tissue analysis, there are different applications for analyzing both specific target regions and all coding regions with non-surgical methods based on the examination of blood samples taken from the patient, also called liquid biopsy.

Cancer Genetics

CancerSelect-R™ 88 Next Generation Sequencing Cancer Panel

This panel examines the 88 best characterized target cancer genes. DNA is isolated from normal and/or tumor samples from the same patient using proprietary methods, including low quality or small quantities of samples. Target regions are amplified using proprietary methods and tumor-specific (somatic) mutations, copy number changes and translocations are detected by high-depth next-generation sequencing. Detailed information about CancerSelect-R™ 88 products from the brochure you can reach.

CancerSelect-R™ 203 Next Generation Sequencing Cancer Panel

Unlike the CancerSelect-R™ 88 panel, this panel examines the 203 best characterized target cancer genes. Detailed information about the product in our brochure you can find.

CancerXome™ Next Generation Sequencing Cancer Panel

CancerXome™ targets and analyzes the coding regions of >20,000 genes. Both tumor and normal samples are prepared using proprietary methods, including low-quality or small-quantity samples. High-depth sequencing detects tumor-specific (somatic) mutations and copy number alterations. Detailed information about this product can be found in the product in our brochure you can find.

ImmunoSelect-R™ Next Generation Sequencing Cancer Panel

Neoantigens are a new class of immunogenic antigens that are completely individual and tumor-specific, present in every patient's tumor. By combining Personal Genome Diagnostics whole exon cancer analysis (CancerXome™) with in-silico neoantigen prediction, ImmunoSelect-R™ identifies and prioritizes the most relevant neoantigens arising from mutations and the resulting data informs adaptive T-cell transfer, cancer vaccine development and prediction of the clinical efficacy of checkpoint inhibitors. More detailed information about ImmunoSelect-R™ can be found in the product from our brochure you can reach.

METDetect-R™ Next Generation Sequencing Cancer Panel

METDetect-R™ analysis, which uses next-generation sequencing to examine the MET tyrosine kinase receptor locus and surrounding regions, is designed to identify mutant alleles to predict response to treatment. By applying this assay to both plasma and tumor tissue samples, MET amplification can be detected in only a very small percentage of DNA molecules (% 0.1). For more information product brochure you can examine.

PlasmaSelect-R™ Next Generation Sequencing Cancer Panel

PlasmaSelect-R™ examines circulating tumor cells to help identify cancer-causing genetic changes without the need for invasive biopsy methods or tumor tissue. PlasmaSelect-R™ examines 63 well-characterized cancer genes. Free circulating tumor DNA is separated from plasma using proprietary methods that enable the extraction of small amounts of DNA. Target regions are amplified using proprietary methods and tumor-specific (somatic) mutations and translocations are identified with high sensitivity and accuracy by high-depth next-generation sequencing. For detailed information about PlasmaSelect-R™ our brochure you can apply.

LungSelect™ Next Generation Sequencing Cancer Panel

LungSelect™ is used to identify the most common somatic mutations and translocations in the plasma of patients with non-small cell lung cancer that allow for clinical intervention. LungSelect™ screens for all of the alterations specified in the guidelines for FDA-approved therapies. For more information, see our product brochure from here you can reach.

Customized Solutions

In addition to these products, PDGx also offers customized solutions. Please contact us for more information.